The Bears (12-9, 10-6 Skyline) started the game on a 16-3 run, aided by Kiley's six points and five by St. Edmund Prep product O'Donnell and teammate Jamie Provino.
The Rams (8-12, 6-10) found the hole before Kiley, a Whitestone native and Archbishop Molloy alum, capped off her 10-point first quarter with four points, giving the Bears a commanding 20-5 lead into the second quarter.
The second stanza began with FSC narrowing their gap to nine. Despite the Bears' offensive struggles in the period, their lead grew to 17, fueled by Samantha Wilber's five points off the bench and the team shooting 7-of-12 from the charity stripe.
Farmingdale State scored the final six points of the half, but the Bears took a 33-22 lead into the intermission.
Kiley's seven and St. Francis Prep grad Quesada's five in the third quarter contributed to St. Joseph's holding on to their double-figure advantage throughout the period, leading by as many as 16.
The visitors mounted a comeback in the fourth quarter, ultimately coming to within a three-pointer of tying with 3:16 left on a layup by Mackenzie Tierney. After Tierney missed the ensuing free throw, O'Donnell went coast to coast and scored a layup and a free throw of her own, giving the Bears some breathing room down the stretch.
With 12 points from O'Donnell in the quarter, the Bears held on for a nine-point win, 70-61.
On 64 percent shooting, Kiley poured in a game-high 25 points along with 12 boards and a pair of blocks, while O'Donnell pulled down a game-high 15 rebounds to go with 19 points.
Up next for the Bears is Yeshiva University at City College in a contest scheduled for Tuesday, February 11.
Men come up short
Coming off of back-to-back victories, the St. Joseph's College men (8-13, 4-8) fell to Farmingdale State College (11-10, 7-5), 81-64.
Four Bears scored 10-plus points in the game, but it wasn't enough as they dropped both in the season series with Farmingdale.
The Bears continuously cut the score to single-digits, but never came closer than eight in a losing effort at home in which they missed 14 free-throws.
Chris Mikos dropped a game-high 17 points on 6-11 shooting and corralled seven boards with three assists, while Hollis native and St. Francis Prep product Stephane Etheart contributed 11 points off the bench.
Matt McQuillen chipped in a season-high nine points on 7-8 from the line, while Frank Reali added 11 points of his own and had five boards with a pair of steals.
Next up is a road test at first-place Yeshiva University on Tuesday, February 11.